Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
J. Clin. Invest. Sefina Arif, et al. 113:451 doi:10.1172/JCI19585 [Go to this article.]

Figure 7
(a) Polarization of autoreactive T cell responses to IA-2 and PI peptides in patients with T1DM (open circles) and nondiabetic control subjects (closed triangles). For any given positive peptide response (SI ≥ 3.0 for IFN-γ or IL-10), the SI for each cytokine has been plotted. There is a highly significant inverse correlation between responses represented by each of these cytokines (P = 0.000004), indicating extreme polarization of proinflammatory and regulatory autoreactivity. Patients with T1DM are clustered close to the y axis, and nondiabetic control subjects are distributed along the x axis, indicating the association of disease and tolerant states with proinflammatory and regulatory responses, respectively. (b) Relationship between age at onset of T1DM and production of IL-10 in response to peptides of IA-2 and PI. Of 24 patients tested, those making IL-10 responses are significantly older (P = 0.01).