Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
J. Clin. Invest. Sefina Arif, et al. 113:451 doi:10.1172/JCI19585 [Go to this article.]

Figure 6
IL-10 ELISPOT analyses in response to medium alone, six IA-2 peptides, three PI peptides, and tetanus toxoid (TT) for patients with T1DM and each nondiabetic control subject. Each graph shows mean (SEM) of triplicate wells for each analysis on each subject (no. 1–36 and C1–C14). Horizontal dashed line represents cut-off of positivity (SI ≥ 3.0 when compared with diluent alone). (a) T1DM patients with at least one HLA-DR4 allele. (b) T1DM patients with non-DR4 alleles. (c) Nondiabetic control subjects. See Table 1 for case identifiers, HLA types, and clinical characteristics of the subjects.