Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
J. Clin. Invest. Scott S. Wagers, et al. 114:104 doi:10.1172/JCI19569 [
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Figure 9The effect of the fibrinolytic agent, tPA, on PV curve hysteresis in mice with inflamed airways. The percentage of increase in the area subtended by the inspiratory and expiratory limb of a PV curve obtained 40 minutes after nebulization of saline or tPA was determined for each individual mouse, and results from all mice in each group were then averaged. Mice exposed to tPA (
n = 6) had significantly smaller PV curve areas compared with those in mice exposed to saline alone (
n = 9): 66.3% ± 15% compared with 130% ± 25%.
