Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
J. Clin. Invest. Scott S. Wagers, et al. 114:104 doi:10.1172/JCI19569 [Go to this article.]

Figure 8
Subepithelial fibrosis in mice with allergic airway inflammation. Staining with Sirius red of lung sections from naive BALB/c mice (A) and those with allergic airway inflammation (B) is shown. Sirius red is a dye that stains collagen specifically. Scoring by masked observers demonstrated a significant increase in subepithelial collagen deposition in mice with allergic airway inflammation (score: 1.14 ± 0.1 naive, n = 7; 1.96 ± 0.26 inflamed, n = 8; P < 0.01). Inflamed mice that received nebulized tPA (C) showed no reduction in subepithelial collagen deposition compared with inflamed mice that received saline only (score: 1.96 ± 0.2, n = 8, inflamed + tPA; 1.96 ± 0.26, n = 8, inflamed + saline).