Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
J. Clin. Invest. Scott S. Wagers, et al. 114:104 doi:10.1172/JCI19569 [Go to this article.]

Figure 5
Effect of fibrinogen or thrombin alone on airway hyperresponsiveness. Mice given nebulized fibrinogen followed by thrombin (n = 7) had significantly increased airway hyperresponsiveness to methacholine in all parameters compared with mice that received fibrinogen alone (n = 6) or thrombin alone (n = 6): R_n (fibrinogen followed by thrombin, 9.8 ± 2.9; fibrinogen alone, 23.8 ± 4.8, P < 0.03; thrombin alone, 23.2 ± 5.0, P < 0.04), G_ti (fibrinogen followed by thrombin, 8.5 ± 1.3; fibrinogen alone, 12.5 ± 1.0, P < 0.04; thrombin alone, 12.6 ± 1.3, P < 0.05), H_ti (fibrinogen followed by thrombin, 5.5 ± 1.7; fibrinogen alone, 10.4 ± 1.0, P < 0.04; thrombin alone, 26 ± 8.2, P < 0.03).