Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
J. Clin. Invest. Scott S. Wagers, et al. 114:104 doi:10.1172/JCI19569 [Go to this article.]

Figure 3
Quantification of fibrin. Relative amounts of intact fibrin were determined by subjecting the lavage samples to fibrin digestion with plasmin. The graph depicts predigestion (Before) and postdigestion (After) concentrations of D-dimer in lavage fluid. Mice that been exposed to nebulized fibrinogen followed by thrombin (Fibrin) (n = 8) are compared with mice that had allergic airway inflammation (OVA) (n = 10). Predigestion D-dimer concentrations are the highest in the fibrin mice (9.7 ± 2.1; 5.61 ± 1.0). Postdigestion concentration of D-dimer in BAL from OVA mice (12.6 ± 0.8) was similar to postdigestion D-dimer concentration in fibrin mice (13.1 ± 2.0). OVA mice had a larger difference between postdigestion and predigestion BAL D-dimer concentration (7.0 ± 1.4) compared with BAL from fibrin mice (3.39 ± 2.7). This indicates that greater amounts of intact fibrin is present on the airway surface of OVA mice.