Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
J. Clin. Invest. Scott S. Wagers, et al. 114:104 doi:10.1172/JCI19569 [
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Figure 10PV curves from mice with allergic airway inflammation that had been exposed to saline or tPA. PV curves that were generated with a stepwise volume insufflation of an in vivo mouse preparation are shown here with pressure on the abscissa and volume on the ordinate. Mice exposed to tPA exhibited curves characterized by lower pressures at each volume increment. The inspiratory curve is shifted to the left in the mice exposed to tPA, demonstrating an increase in lung compliance consistent with enhanced function of surfactant.
