Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
J. Clin. Invest. Scott S. Wagers, et al. 114:104 doi:10.1172/JCI19569 [Go to this article.]

Figure 1
Fibrin immunostaining. H&E staining of a human lung from a patient who died due to status asthmaticus (A) (magnification ×10) and a lung from a mouse with allergic airway inflammation (B) (magnification ×20) are shown as a structural reference for the immunostaining. Immunostaining with a mouse IgG that selectively binds to the β chain of both mouse and human fibrin is shown (C and D). Red reaction product indicating the presence of fibrin (white arrowheads) is seen within the parenchyma and airways in both the human and mouse lung sections. Immunostaining in which a nonspecific mouse IgG was used is shown as an isotype control (E and F).