JCI - Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
J. Clin. Invest. 113:10 doi:10.1172/JCI19560 [Go to this article.]

Options: View larger image (or click on image)

Figure 5

Expression of hCD39 protects hearts from rejection in an allograft model of cardiac xenotransplantation. Immunohistochemical analysis of grafts removed at 24 hours after Ab injection, demonstrating preserved morphology and minimal platelet deposition in capillaries (arrow) in transgenic grafts. In contrast, WT grafts show a heavy platelet infiltrate (arrow) and destruction of myocardial architecture (magnification ∞20).