Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
J. Clin. Invest. Esra Asilmaz, et al. 113:414 doi:10.1172/JCI19511 [Go to this article.]

Figure 6
Dose-response curve for leptin treatment. Leptin corrects hyperinsulinemia and hyperglycemia at leptin doses that have no effect on SCD activity and gross liver appearance (50 ng/h and 100 ng/h). (a) Liver triglyceride content. (b) SCD enzymatic activity measured in liver extracts of aP2-nSREBP-1c mice treated with several doses of subcutaneous leptin. (c and d) Plasma glucose and plasma insulin levels, respectively. Error bars indicate the SE; n = 3 for 12 ng/h and 25 ng/h leptin, and n = 4 for 0 ng/h, 50 ng/h, 100 ng/h, and 200 ng/h leptin. *P < 0.005, 200-ng/h leptin dose vs. 0-ng/h dose. ^#P < 0.05, 50-ng/h leptin dose vs. 0-ng/h dose.