Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
J. Clin. Invest. Esra Asilmaz, et al. 113:414 doi:10.1172/JCI19511 [
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Figure 4Regulation of SCD-1 by icv leptin. SCD-1 mRNA levels and enzyme activity are shown for aP2-nSREBP-1c transgenic mice treated with icv PBS, icv leptin, and WT littermate controls. (
a) TaqMan real-time PCR of liver RNA samples using primers and probe specific for SCD-1. (
b) Enzymatic activity measured in liver extracts. Error bars indicate the SE;
n = 4 for icv PBS and icv leptin, and
n = 6 for the WT group. *
P < 0.05, icv leptin vs. icv PBS.
