Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
J. Clin. Invest. Esra Asilmaz, et al. 113:414 doi:10.1172/JCI19511 [Go to this article.]

Figure 1
Effects of central and peripheral leptin in rodent lipodystrophy. Several metabolic parameters in aP2-nSREBP-1c transgenic mice treated with icv PBS, icv leptin (12 ng/h), and subcutaneous leptin (200 ng/h) are shown. (a, d, and e) Plasma levels of leptin, glucose, and insulin, respectively. (b) Average daily food intake for the 12-day treatment. (c) Percentage change in body weight. One hundred percent change indicates the weight of the mice on the day of pump insertion. Error bars indicate the SE for four mice per group for each treatment. *P < 0.05, icv leptin vs. icv PBS.