Blockade of T cell costimulation reveals interrelated actions of CD4⁺ and CD8⁺ T cells in control of SIV replication
J. Clin. Invest. David A. Garber, et al. 113:836 doi:10.1172/JCI19442 [Go to this article.]

Figure 3
Reduction of acute SIV viral load is directly related to CD8⁺ T cell proliferative responses. Correlation of the magnitude of postpeak decline in SIV viremia and Gag_181–189-specific (A), Tat_28–35-specific (B), and Ki67⁺ (C) CD8⁺ T cells. The magnitude of the postpeak decline in SIV viremia is reported as the logarithm of the fold reduction of SIV viremia between peak and day 27 after infection (last day of treatment). All CD8⁺ T cell parameters were calculated as AUCs from baseline through day 27 after infection. Control macaques (circles): ROz5 (black), RBm6 (blue), RVy5 (red), RYt5 (green); CS blockade macaques (triangles): REp6 (black), REo6 (blue), RIc6 (red), RCr5 (green). P and ρ values were determined by the Spearman rank correlation test. The solid lines are regression lines.