Blockade of T cell costimulation reveals interrelated actions of CD4⁺ and CD8⁺ T cells in control of SIV replication
J. Clin. Invest. David A. Garber, et al. 113:836 doi:10.1172/JCI19442 [Go to this article.]

Figure 1
Effects of CS blockade on SIV replication. (A) SIV viral load (log₁₀ SIV RNA copies per milliliter plasma) from macaques in the control group (left panel) or CS blockade treatment group (right panel). Indicated are times at which individual macaques were sacrificed because of clinical deterioration due to simian AIDS (circled x). Control macaques: ROz5 (black), RBm6 (blue), RVy5 (red), RYt5 (green). CS blockade macaques: REp6 (black), REo6 (blue), RIc6 (red), RCr5 (green). The gray bar denotes the treatment period. (B) Geometric mean SIV viral load (log₁₀ SIV RNA copies per milliliter plasma) for CS blockade group (red) and control group (black). The yellow shading indicates times at which significant differences were determined between groups (P ≤ 0.05, repeated measures analysis of means). The gray bar denotes the treatment period.