Citations to this article


Studies of B cell antigen receptors (BCRs) expressed by leukemic lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) suggest that B lymphocytes with some level of BCR structural restriction become transformed. While analyzing rearranged VHDJH and VLJL genes of 25 non–IgM-producing B-CLL cases, we found five IgG+ cases that display strikingly similar BCRs (use of the same H- and L-chain V gene segments with unique, shared heavy chain third complementarity-determining region [HCDR3] and light chain third complementarity-determining region [LCDR3] motifs). These H- and L-chain characteristics were not identified in other B-CLL cases or in normal B lymphocytes whose sequences are available in the public databases. Three-dimensional modeling studies suggest that these BCRs could bind the same antigenic epitope. The structural features of the B-CLL BCRs resemble those of mAb’s reactive with carbohydrate determinants of bacterial capsules or viral coats and with certain autoantigens. These findings suggest that the B lymphocytes that gave rise to these IgG+ B-CLL cells were selected for this unique BCR structure. This selection could have occurred because the precursors of the B-CLL cells were chosen for their antigen-binding capabilities by antigen(s) of restricted nature and structure, or because the precursors derived from a B cell subpopulation with limited BCR heterogeneity, or both.


Fabio Ghiotto ... Manlio Ferrarini, Nicholas Chiorazzi


Total citations by year

Year: 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 3 13 9 6 11 5 12 11 14 10 8 5 107
Citation information

Citations to this article in year 2008 (11)

Title and authors Publication Year
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
CC Chu, R Catera, K Hatzi, XJ Yan, L Zhang, XB Wang, HM Fales, SL Allen, JE Kolitz, KR Rai, N Chiorazzi
Blood 2008
Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor
M Colombat, H Mal, C Copie-Bergman, J Diebold, D Damotte, P Callard, M Fournier, JP Farcet, M Stern, MH Delfau-Larue
Blood 2008
Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation
P Ghia, N Chiorazzi, K Stamatopoulos
Journal of Internal Medicine 2008
Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3
GF 2nd, CJ Goldberg, TL Toy, LZ Rassenti, WG Wierda, JC Byrd, MJ Keating, JG Gribben, KR Rai, TJ Kipps
Blood 2008
Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients
RC Tschumper, SM Geyer, ME Campbell, NE Kay, TD Shanafelt, CS Zent, GS Nowakowski, TG Call, GW Dewald, DF Jelinek
Journal of Clinical Investigation 2008
Chronic lymphocytic leukemia: "Cinderella" is becoming a star
F Caligaris-Cappio
Molecular Medicine 2008
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
A Hadzidimitriou, N Darzentas, F Murray, T Smilevska, E Arvaniti, C Tresoldi, A Tsaftaris, N Laoutaris, A Anagnostopoulos, F Davi, P Ghia, R Rosenquist, K Stamatopoulos, C Belessi
Blood 2008
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
M Muzio, B Apollonio, C Scielzo, M Frenquelli, I Vandoni, V Boussiotis, F Caligaris-Cappio, P Ghia
Blood 2008
Chronic lymphocytic leukaemia
G Dighiero, TJ Hamblin
The Lancet 2008
Chronic lymphocytic leukaemia: An immunobiology approach
E Kostareli, T Smilevska, K Stamatopoulos, A Kouvatsi, A Anagnostopoulos
Srpski arhiv za celokupno lekarstvo 2008
Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
D Rossi, M Cerri, D Capello, C Deambrogi, FM Rossi, A Zucchetto, LD Paoli, S Cresta, S Rasi, V Spina, S Franceschetti, M Lunghi, C Vendramin, R Bomben, A Ramponi, G Monga, A Conconi, C Magnani, V Gattei, G Gaidano
British Journal of Haematology 2008