Citations to this article


Studies of B cell antigen receptors (BCRs) expressed by leukemic lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) suggest that B lymphocytes with some level of BCR structural restriction become transformed. While analyzing rearranged VHDJH and VLJL genes of 25 non–IgM-producing B-CLL cases, we found five IgG+ cases that display strikingly similar BCRs (use of the same H- and L-chain V gene segments with unique, shared heavy chain third complementarity-determining region [HCDR3] and light chain third complementarity-determining region [LCDR3] motifs). These H- and L-chain characteristics were not identified in other B-CLL cases or in normal B lymphocytes whose sequences are available in the public databases. Three-dimensional modeling studies suggest that these BCRs could bind the same antigenic epitope. The structural features of the B-CLL BCRs resemble those of mAb’s reactive with carbohydrate determinants of bacterial capsules or viral coats and with certain autoantigens. These findings suggest that the B lymphocytes that gave rise to these IgG+ B-CLL cells were selected for this unique BCR structure. This selection could have occurred because the precursors of the B-CLL cells were chosen for their antigen-binding capabilities by antigen(s) of restricted nature and structure, or because the precursors derived from a B cell subpopulation with limited BCR heterogeneity, or both.


Fabio Ghiotto ... Manlio Ferrarini, Nicholas Chiorazzi


Total citations by year in Crossref

Year: 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 2 7 3 3 5 5 8 6 12 7 4 3 65
Citation information

Citations to this article in Crossref (65)

Title and authors Publication Year
The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia
LA Sutton, R Rosenquist
Seminars in Cancer Biology 2015
Pre-malignant lymphoid cells arise from hematopoietic stem/progenitor cells in chronic lymphocytic leukemia
Y Kikushige, T Miyamoto
International Journal of Hematology 2015
In vitro induction of antibody secretion of primary B-cell chronic lymphocytic leukaemia cells
R Hoogeboom, RJ Reinten, JJ Schot, JE Guikema, RJ Bende, CJ van Noesel
Leukemia 2014
The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs
M Schaller, M Vogel, K Kentouche, B Lammle, JA Hovinga
Blood 2014
Antibody structural modeling with prediction of immunoglobulin structure (PIGS)
P Marcatili, PP Olimpieri, A Chailyan, A Tramontano
Nature Protocols 2014
Advances in Immunology
AM Avalos, F Meyer-Wentrup, HL Ploegh
Advances in immunology 2014
Stereotyped B-cell receptors in chronic lymphocytic leukemia
A Agathangelidis, A Vardi, P Baliakas, K Stamatopoulos
Leukemia & Lymphoma 2014
Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma
A Mahendra, B Gangadharan, S André, M Boudjoghra, F Davi, M Lecerf, C Planchais, SV Kaveri, S Lacroix-Desmazes, JD Dimitrov
Molecular Immunology 2014
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells
V Seda, M Mraz
European Journal of Haematology 2014
Immunoglobulin Gene Rearrangements and Mutational Status in Argentinian Patients With Chronic Lymphocytic Leukemia
C Stanganelli, A Travella, R Bezares, I Slavutsky
Clinical Lymphoma Myeloma and Leukemia 2013
CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL
M Binder, F Muller, M Frick, C Wehr, F Simon, B Leistler, H Veelken, R Mertelsmann, M Trepel
Blood 2013
Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2
JC Strefford, LA Sutton, P Baliakas, A Agathangelidis, J Malčíková, K Plevova, L Scarfó, Z Davis, E Stalika, D Cortese, N Cahill, LB Pedersen, PF di Celle, T Tzenou, C Geisler, P Panagiotidis, AW Langerak, N Chiorazzi, S Pospisilova, D Oscier, F Davi, C Belessi, L Mansouri, P Ghia, K Stamatopoulos, R Rosenquist
Leukemia 2013
Mutational Status and Gene Repertoire of IGHV-IGHD-IGHJ Rearrangements in Serbian Patients With Chronic Lymphocytic Leukemia
T Karan-Djurasevic, V Palibrk, T Kostic, V Spasovski, G Nikcevic, S Srzentic, M Colovic, N Colovic, A Vidovic, D Antic, B Mihaljevic, S Pavlovic, N Tosic
Clinical Lymphoma Myeloma and Leukemia 2012
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
MD Minden, R Übelhart, D Schneider, T Wossning, MP Bach, M Buchner, D Hofmann, E Surova, M Follo, F Köhler, H Wardemann, K Zirlik, H Veelken, H Jumaa
Nature 2012
Pathogenesis of Human B Cell Lymphomas *
AL Shaffer, RM Young, LM Staudt
Annual Review of Immunology 2012
Biased immunoglobulin genes rearrangement in mantle cell lymphoma: Hints to identify the normal B-cell counterpart
H Zhang, H Wang, X Hao, D Capello, SB Cogliatti, F Bertoni, F Cavalli
Clinical Oncology and Cancer Research 2011
Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
AA Warsame, HC Aasheim, K Nustad, G Troen, A Tierens, V Wang, U Randen, HP Dong, S Heim, A Brech, J Delabie
Blood 2011
New insights into the pathobiology of chronic lymphocytic leukemia
R Gunnarsson, R Rosenquist
Journal of Hematopathology 2011
J Gavalchin
Encyclopedia of Life Sciences 2011
Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia
Y Kikushige, F Ishikawa, T Miyamoto, T Shima, S Urata, G Yoshimoto, Y Mori, T Iino, T Yamauchi, T Eto, H Niiro, H Iwasaki, K Takenaka, K Akashi
Cancer Cell 2011
Activation-induced cytidine deaminase splicing patterns in chronic lymphocytic leukemia
F Marantidou, A Dagklis, E Stalika, P Korkolopoulou, A Saetta, A Anagnostopoulos, N Laoutaris, K Stamatopoulos, C Belessi, Z Scouras, E Patsouris
Blood Cells, Molecules, and Diseases 2010
Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution
E Kostareli, LA Sutton, A Hadzidimitriou, N Darzentas, A Kouvatsi, A Tsaftaris, A Anagnostopoulos, R Rosenquist, K Stamatopoulos
Leukemia 2010
The B cell antigen receptor in atypical chronic lymphocytic leukemia with t(14;19)(q32;q13) demonstrates remarkable stereotypy
CD Schweighofer, YO Huh, R Luthra, RL Sargent, RP Ketterling, RA Knudson, LL Barron, LJ Medeiros, MJ Keating, LV Abruzzo
International Journal of Cancer 2010
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease
F Palacios, P Moreno, P Morande, C Abreu, A Correa, V Porro, AI Landoni, R Gabus, M Giordano, G Dighiero, O Pritsch, P Oppezzo
Blood 2010
Antigens in chronic lymphocytic leukemia—Implications for cell origin and leukemogenesis
A Rosén, F Murray, C Evaldsson, R Rosenquist
Seminars in Cancer Biology 2010