Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues
J. Clin. Invest. James C. Lo, et al. 112:1495 doi:10.1172/JCI19188 [Go to this article.]

Figure 1
Leukocyte accumulation in lungs of LT-deficient mice. (a) Increased numbers of CD4⁺, B220⁺, and DCs in lungs of LTα^–/– mice. Data are mean ± SD of triplicate samples and represent at least three independent experiments. (b) CCR7 expression on naive and activated phenotype pulmonary CD4⁺ T cells. Representative dot plots and histograms of CCR7 chemokine expression using ELC-Fc (blue lines) compared to control human-Fc (red lines) on CD4⁺CD62L^high and CD4⁺CD62L^low cells. (c) Altered homing of CD4⁺ T cells to the lungs of LTβR^–/– mice. The spleens and lungs of WT and LTβR^–/– mice were analyzed for the presence of OTII cells 2 days after adoptive transfer i.p. of Thy1.1⁺ OTII cells. Data are mean ± SD of four or more mice per group. *P < 0.05 between WT lung and WT spleen, and WT lung and LTβR^–/– lung as calculated by the Student’s t test. Max, maximum.