Wolfgang W. Leitner, Nicholas P. Restifo
J Clin Invest.
2003;
112(1):22–24
doi:10.1172/JCI19069
This article Copyright © 2003, The American Society for Clinical Investigation
Abstract
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T
he apoptotic machinery has become the latest target of vaccinologists attempting to improve the efficacy of DNA vaccines. While workers have previously sought to induce apoptotic death in transfected DCs as a means to activate immunity, a new approach (see related article on pages 109–117) instead seeks to delay apoptosis in host DCs after DNA vaccination.
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