Bone marrow–derived progenitor cells in pulmonary fibrosis
J. Clin. Invest. Naozumi Hashimoto, et al. 113:243 doi:10.1172/JCI18847 [
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Figure 2Lung morphology of BM chimera mice. Representative lung sections from GFP BM chimera mice were examined on day 28 (
a and
c) and day 56 (
b and
d) after BMT, by light microscopy (
a and
b, H&E-stained sections) and fluorescence microscopy (
c and
d). At day 28 after BMT (
a), lungs from GFP BM chimera mice revealed essentially normal lung architecture and no evidence of pneumonitis. At day 56 after BMT (
b), the lungs also appeared essentially normal, except for a few scattered inflammatory cells. Only a few GFP
+ cells were present in lung sections on both days 28 (
c) and 56 (
d) after BMT. Insets in
c and
d showed light-microscopic images of the unstained sections used for fluorescence microscopy. All images were photographed at ×100.