The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease
J. Clin. Invest. Shreeram Akilesh, et al. 113:1328 doi:10.1172/JCI18838 [Go to this article.]

Figure 3
Both FcRn and Fcgr2 are required for IVIg to ameliorate arthritis. Mice were injected intraperitoneally with K/BxN serum on day 0 and treated intraperitoneally on days _1, 1, 2, and 3 with 25 mg (1 ± 1 g/kg/mouse) IVIg (open circles) or HSA (filled circles). (A) K/BxN serum (500 ∝l) was injected into B6-FcRn^+/+ Fcgr2^+/+ mice (n = 3). Left panel, ankle width; right panel, anti-GPI Ab’s. Representative of two independent experiments. (B) K/BxN serum (500 ∝l) injected into B6-FcRn^+/+ Fcgr2^_/_ mice (n = 5). Left panel, ankle width; right panel, anti-GPI Ab’s. Representative of four independent experiments using either 250 or 500 ∝l K/BxN serum. (C) K/BxN serum (500 ∝l) injected into B6-FcRn^_/_ Fcgr2^+/+ mice (n = 4). Left panel, ankle width; right panel, anti-GPI Ab’s. Representative of two independent experiments. (D) K/BxN serum (500 ∝l; left panel) or (1,000 ∝l; right panel) injected into FcRn^_/_ Fcgr2^_/_ mice (n = 3_4). *P < 0.05, **P < 0.01, P < 0.001, ^#P < 0.0001. All other time points were not significant at P < 0.05.