RAGE^–/– and Tie2RAGE mice develop a normal immune response in EAE. Age- and sex-matched mice were sensitized against oligodendrocyte glycoprotein (MOG35–55) and were monitored for the onset of clinical signs on a daily basis (see Methods). (A) EAE response in WT and RAGE^–/– mice. WT indicates C57BL/6 ∞ 129/Sv mice. The mean clinical score represents a summary of two independent experiments each for WT and for RAGE^–/–. WT, filled squares; RAGE^–/–, open circles. (B) EAE response in WT and Tie2RAGE mice. WT mice used were transgene-negative littermates. The mean clinical score represents a summary of two independent experiments each for WT and for Tie2RAGE. WT, filled squares; Tie2RAGE, open triangles. The standard error of the mean is given (± SEM), and P < 0.05 was considered to be statistically significant.