Advertisement

Citations to this article

Abstract

Mutation of the murine maturity-onset diabetes mellitus of the young (Mody) locus induces diabetes, but the effects of its homozygosity on the pancreas remain unknown. F2 mice were obtained by F1 (diabetic C57BL6 x normal Mus musculus castaneus) crosses. About 20% of the F2 progeny developed diabetes by 2 wk of age, 50% of the progeny were normal at 2 wk and developed diabetes between 5 and 8 wk of age, and the remaining 30% did not develop diabetes. Quantitative trait locus analysis using blood glucose levels of 118 F2 mice at 2 wk of age and 5-8 wk of age located Mody within 3 cM of D7Mit258. Histopathological investigation revealed hypoplastic islets (approximately 33% of that of wild-type mice) and a lower density of beta cells (approximately 20% of wild-type) with a reciprocal dominance of alpha cells (four times that of wild-type) in Mody homozygotes. Electron microscopic observations revealed a specific decrease in the number of insulin secretory granules and a lower density of beta cells. Ratios of insulin to glucagon contents confirmed specific decreases in insulin content: 0.01 for homozygotes, 0.54 for heterozygotes, and 1.11 for wild-type mice on day 14. These results suggest that Mody is involved in both islet growth and beta cell function.

Authors

T Kayo, A Koizumi

×

Total citations by year

Year: 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2000 1999 Total
Citations: 3 7 7 6 4 2 6 1 1 1 1 3 1 1 44
Citation information

Citations to this article (44)

Title and authors Publication Year
Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin
SY Park, MZ Ludwig, NA Tamarina, BZ He, SH Carl, DA Dickerson, L Barse, B Arun, CL Williams, CM Miles, LH Philipson, DF Steiner, GI Bell, M Kreitman
Genetics 2013
Involvement of ASK1–p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion
K Yamaguchi, K Takeda, H Kadowaki, I Ueda, Y Namba, Y Ouchi, H Nishitoh, H Ichijo
Biochimica et Biophysica Acta (BBA) - General Subjects 2013
Interactive network analysis of the plasma amino acids profile in a mouse model of hyperglycemia
T Tanaka, T Mochida, Y Maki, Y Shiraki, H Mori, S Matsumoto, K Shimbo, T Ando, K Nakamura, F Endo, M Okamoto
SpringerPlus 2013
Diabetic modifier QTL, Dbm4, affecting elevated fasting blood glucose concentrations in congenic mice
S Takeshita, S Kitayama, T Suzuki, M Moritani, H Inoue, M Itakura
Genes & Genetic Systems 2012
Loss of TIMP3 selectively exacerbates diabetic nephropathy
R Basu, J Lee, Z Wang, VB Patel, D Fan, SK Das, GC Liu, R John, JW Scholey, GY Oudit, Z Kassiri
American journal of physiology. Renal physiology 2012
Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring
C Grasemann, MJ Devlin, PA Rzeczkowska, R Herrmann, B Horsthemke, BP Hauffa, M Grynpas, C Alm, ML Bouxsein, MR Palmert
PloS one 2012
Transgenic zebrafish model of the C43G human insulin gene mutation
SC Eames, MD Kinkel, S Rajan, VE Prince, LH Philipson
Journal of Diabetes Investigation 2012
Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2+/Akita β-Cells
Q Yuan, W Tang, X Zhang, JA Hinson, C Liu, K Osei, J Wang
PloS one 2012
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
M Maris, L Overbergh, C Gysemans, A Waget, AK Cardozo, E Verdrengh, JP Cunha, T Gotoh, M Cnop, DL Eizirik, R Burcelin, C Mathieu
Diabetologia 2012
Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice
CK Yeh, SE Harris, S Mohan, D Horn, R Fajardo, YH Chun, J Jorgensen, M MacDougall, S Abboud-Werner
Laboratory Investigation 2012
Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2
Y Gu, Y Mao, H Li, S Zhao, Y Yang, H Gao, J Yu, X Zhang, DM Irwin, G Niu, H Tan
Translational Research 2011
Insulin gene mutations and diabetes
M Nishi, K Nanjo
Journal of Diabetes Investigation 2011
A Model of Threshold Behavior Reveals Rescue Mechanisms of Bystander Proteins in Conformational Diseases
CI Sandefur, S Schnell
Biophysical Journal 2011
Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice
H Chen, C Zheng, X Zhang, J Li, J Li, L Zheng, K Huang
Peptides 2011
Endoplasmic reticulum stress and pancreatic beta cell death
SG Fonseca, J Gromada, F Urano
Trends in endocrinology and metabolism: TEM 2011
Hyperglycemic Ins2AkitaLdlr−/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease[S]
C Zhou, B Pridgen, N King, J Xu, JL Breslow
Journal of lipid research 2011
Time-dependent changes in the plasma amino acid concentration in diabetes mellitus
T Mochida, T Tanaka, Y Shiraki, H Tajiri, S Matsumoto, K Shimbo, T Ando, K Nakamura, M Okamoto, F Endo
Molecular Genetics and Metabolism 2011
Proinsulin misfolding and diabetes: Mutant INS gene-induced Diabetes of Youth
M Liu, I Hodish, L Haataja, R Lara-Lemus, G Rajpal, J Wright, P Arvan
Trends in endocrinology and metabolism: TEM 2010
A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β)
X Lei, S Zhang, B Emani, SE Barbour, S Ramanadham
Diabetes, Obesity and Metabolism 2010
Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport
M Liu, L Haataja, J Wright, NP Wickramasinghe, QX Hua, NF Phillips, F Barbetti, MA Weiss, P Arvan
PloS one 2010
The binary switch that controls the life and death decisions of ER stressed beta cells
CM Oslowski, F Urano
Current Opinion in Cell Biology 2010
Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death
X Lei, SE Barbour, S Ramanadham
Biochimie 2010
Toward a More Rational Field-Genetic Epidemiology
A KOIZUMI
Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 2010
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
I Hodish, M Liu, G Rajpal, D Larkin, RW Holz, A Adams, L Liu, P Arvan
The Journal of biological chemistry 2009
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1
X Lei, S Zhang, SE Barbour, A Bohrer, EL Ford, A Koizumi, FR Papa, S Ramanadham
The Journal of biological chemistry 2009

Advertisement
Advertisement