Regulatory functions of CD8⁺CD28^– T cells in an autoimmune disease model
J. Clin. Invest. Nader Najafian, et al. 112:1037 doi:10.1172/JCI17935 [Go to this article.]

Figure 5
H&E and LFB stains of sections of the brainstem and spinal cords from CD28^–/–CD8^–/– mice with typical EAE (a–c) and CD28^–/–CD8^–/– mice with atypical EAE (d–f). (a) H&E-stained section from the anterior pons showing no inflammatory infiltrates. (b) LFB staining in the pons showing no demyelination. (c) LFB staining showing small infiltrate and demyelination in the lateral lumbar spinal cord (arrow). (d) H&E-stained section from pons showing inflammatory infiltrate in the anterior pons (arrow). (e) LFB staining showing demyelination in the anterior pons (arrow). (f) LFB staining showing demyelination and large inflammatory infiltrates in the lateral thoracic spinal cord (arrow). Photomicrographs a–f are taken at ×400 magnification. Enlargements are all at ×1,000 magnification.