Regulatory functions of CD8⁺CD28^– T cells in an autoimmune disease model
J. Clin. Invest. Nader Najafian, et al. 112:1037 doi:10.1172/JCI17935 [Go to this article.]

Figure 3
Induction of EAE in CD28^–/–CD8^–/– and CD28^–/–CD8^+/– mice. (a) Complete lack or decreased expression of CD8 molecule leads to EAE. The mean daily grade for each group (n = 8–15 mice) is on the y axis. All CD28^–/–CD8^–/– mice immunized with MOG developed EAE (open circles): 7 of 15 animals developed a mild form of typical EAE, while 8 of 15 animals developed an atypical form of EAE that led to death in these animals within 24 hours. CD28^–/–CD8^+/– mice developed mild typical EAE that was half-way between that in CD28^–/– (filled triangles) and CD28^–/–CD8^–/– mice (open circles), indicating a dose-response effect of CD8 expression (open squares). (b) Comparison of CD8 surface expression on peripheral blood lymphocytes derived from CD28^–/– mice (solid histogram) and CD28^–/–CD8^+/– mice (line histogram).