Regulatory functions of CD8⁺CD28^– T cells in an autoimmune disease model
J. Clin. Invest. Nader Najafian, et al. 112:1037 doi:10.1172/JCI17935 [Go to this article.]

Figure 2
Effect of lack of CD8⁺ T cells on MOG p35–55–induced EAE in WT C57BL/6 and CD28^–/– mice. (a) Mice were immunized with MOG p35–55 and graded for disease daily. The mean daily grade for each group is shown. This is a representative experiment showing the disease course in C57BL/6 mice treated with rat IgG (filled squares), WT mice treated with anti-CD8 mAb (open circles), and CD8^–/– mice (open squares). (b) A representative experiment showing disease induction in C57BL/6 WT mice (filled squares), CD28^–/– mice treated with control rat IgG (filled triangles), and CD28^–/– mice treated by anti-CD8 mAb before immunization (open circles). The mean daily grade for each group (n = 5–7) is shown.