In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning
J. Clin. Invest. Steven P. Zielske, et al. 112:1561 doi:10.1172/JCI17922 [Go to this article.]

Figure 3
Analysis of the presence of human cells in NOD/SCID mice. (a) Eight to ten weeks after transplant, mouse bone marrow was stained for human CD45 and analyzed by flow cytometry. CD45⁺ levels were below detection in untreated, in once-treated, and in one of five twice-treated mice. Human cells were detectable in four of five twice-treated mice. (b) Human CFUs recovered from NOD/SCID bone marrow were counted and are displayed as CFCs per 10⁶ nucleated cells. Only twice-treated mice showed significant numbers of human CFCs. x, undetectable.