Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions
J. Clin. Invest. Catherine B. Renard, et al. 114:659 doi:10.1172/JCI17867 [Go to this article.]

Figure 1
Diabetic mice demonstrated hyperglycemia throughout the study, and their metabolic control was improved by intense insulin therapy. Female LDLR^–/–;GP littermate mice were injected with saline (nondiabetic) or LCMV (diabetic) 1 week prior to changing the diet at week 0. The diets contained 0%, 0.12%, or 0.5% cholesterol (see key). One group of diabetic mice was treated with an intense insulin therapy (intense insulin) and fed the cholesterol-free diet. Blood glucose was measured at the indicated times. The number of animals per group is indicated within parentheses. NS, nonsignificant versus nondiabetic mice fed the cholesterol-free diet. *P < 0.05, **P < 0.01, ***P < 0.001.