IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation
J. Clin. Invest. Önder Alpdogan, et al. 112:1095 doi:10.1172/JCI17865 [Go to this article.]

Figure 7
Posttransplant IL-7 administration decreases apoptotic T cells in 9-month-old recipients of allogeneic BMT. (a–c) CBA/J mice (3 months or 9 months old) were transplanted as described in Figure 1 without the addition of T cells. All recipients received 10 μg/day IL-7 or PBS (control) by intraperitoneal injection from day 21 to day 27. Animals were sacrificed on day 28, and the percentage of donor-derived apoptotic T cells was determined by flow cytometric analysis using annexin V and anti-Ly9.1, -CD4, and -CD8 antibodies. Representative FACS profiles from control and IL-7–treated middle-aged mice are shown in a. The numbers of annexin V–positive donor-derived CD4⁺ or CD8⁺ T cells from normal B10.BR mice and young and middle-aged allogeneic BMT recipients are shown in b and c, respectively. Values represent percentage of apoptotic cells from ten animals per group, expressed as mean ± SEM. P values represent comparisons between IL-7–treated and PBS-treated groups (*P < 0.05).