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ResearchIn-Press PreviewCell biologyEndocrinology
Open Access | 
10.1172/JCI177980
BAF60a-dependent chromatin remodeling preserves β-cell function and contributes to the therapeutic benefits of GLP-1R agonists
Xinyuan Qiu,1 Ruo-Ran Wang,1 Qing-Qian Wu,1 Hongxing Fu,2 Shuaishuai Zhu,1 Wei Chen,3 Wen Wang,4 Haide Chen,5 Xiuyu Ji,1 Wenjing Zhang,1 Dandan Yan,6 Jing Yan,6 Li Jin,6 Rong Zhang,6 Mengjie Shi,1 Ping Luo,1 Yingqing Yang,7 Qintao Wang,1 Ziyin Zhang,1 Wei Ding,8 Xiaowen Pan,1 Chengbin Li,9 Bin Liang,9 Guoji Guo,5 Hai-long Piao,4 Min Zheng,10 Yan Sheng,2 Lingyun Zhu,7 Cheng Hu,11 and Zhuo-Xian Meng1
1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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1Department of Pathology and Pathophysiology and Department of Cardiology of, Zhejiang University School of Medicine, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated, Zhejiang University School of Medicine, Hangzhou, China
3Gan & Lee Pharmaceuticals, Beijing, China
4CAS Key Laboratory of Separation Science for Analytical Chemistry, Chinese Academy of Sciences, Dalian, China
5Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China
6Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7College of Science, National University of Defense Technology, Changsha, China
8Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China
9Center for Life Sciences, Yunnan University, Kunming, China
10The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
11Shanghai Diabetes Institute, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Meng, Z.
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Published October 6, 2025 - More info
Copyright © 2025, Qiu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)