The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
J. Clin. Invest. Daniela Cota, et al. 112:423 doi:10.1172/JCI17725 [
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Figure 4Altered expression of hypothalamic neuropeptides transcripts in
CB1–/– mice. (
a) Representative autoradiographic images showing upregulation of CRH mRNA in the PVN of
CB1–/– hypothalamus. (
b) Densitometric quantification by image analysis of areas of CRH mRNA expression as percentage of control by using four sections from seven animals in each group. *
P < 0.05 vs.
CB1+/+ control. (
c) Representative autoradiographic images showing downregulation of CART mRNA in the DMN, LHA, and ARC of
CB1–/– hypothalamus. (
d) Densitometric quantification by image analysis of areas of CART mRNA expression as percentage of control by using four sections from seven animals in each group. **
P < 0.005 vs.
CB1+/+ control.
