The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
J. Clin. Invest. Daniela Cota, et al. 112:423 doi:10.1172/JCI17725 [
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Figure 1Body weight, body composition and EE of
CB1–/– mice. (
a) Body weight curves in male mice starting at 3 weeks of age. Each data point represents mean ± SEM of 15 mice. *
P < 0.05 vs.
CB1+/+ littermates. (
b) NMR imaging performed in 16-week-old mice. White arrow, visceral fat; black arrow, subcutaneous fat; T, testis; B, bladder. (
c) Analysis of body composition by quantitative NMR. Fat mass and lean mass expressed as percentage of the body weight. The columns represent the mean ± SEM of 15
CB1+/+ and
CB1–/– mice, respectively. *
P < 0.05 and **
P < 0.005 vs.
CB1+/+ controls. (
d) EE in male
CB1+/+ and
CB1–/– mice. Data are normalized to LBM. Each data point represents mean ± SEM of six mice.
