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The intricate interplay among body weight, stress, and the immune response to friend or foe
Lawrence Steinman, Paul Conlon, Rich Maki, Alan Foster
Published in Volume 111, Issue 2
J Clin Invest. 2003; 111(2):183–185 doi:10.1172/JCI17622
This article Copyright © 2003, The American Society for Clinical Investigation
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Figure 1

Body fat and the autoimmune response. Decreases in body fat or starvation increase CRF levels and decrease leptin levels. Increased CRF downregulates Th1 immunity (5) as does decreased leptin (4). Other molecules of the α-MSH family stimulate Th1 T cells via their MC-4 receptor. CRFR, CRF receptor; LepR, leptin receptor.

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