Critical role of galectin-3 in phagocytosis by macrophages
J. Clin. Invest. Hideki Sano, et al. 112:389 doi:10.1172/JCI17592 [Go to this article.]

Figure 3
Impaired IgG-mediated phagocytosis of erythrocytes in gal3^–/– mice in vivo. Experimental autoimmune hemolytic anemia was induced by an intraperitoneal injection of the anti–mouse rbc mAb 34-3C. (a) Three days after the injection, hematocrit was measured. The results are the mean ± SD from four mice of each genotype. (b) Liver sections of wild-type and gal3^–/– mice were prepared and processed for H&E staining (original magnification, ×400). Open arrowheads point to Kupffer cells that do not contain rbc’s and filled arrowheads point to those with phagocytosed rbc’s. Arrows point to extramedullary hematopoietic foci. The inset shows a single Kupffer cell demonstrating erythrophagocytosis (original magnification, ×1,000).