Critical role of galectin-3 in phagocytosis by macrophages
J. Clin. Invest. Hideki Sano, et al. 112:389 doi:10.1172/JCI17592 [
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Figure 2Reduced phagocytosis of apoptotic thymocytes by
gal3–/– macrophages. (
a) In vitro phagocytosis of apoptotic thymocytes by macrophages was performed and the phagocytic index was calculated following 20-minute incubation of these cells. Data shown represent the mean ± SD from six experiments (
P < 0.001). (
b) Scatter plots of the percentage of macrophages containing phagocytosed apoptotic thymocytes and/or apoptotic bodies 30 minutes after injection of the cells into the peritoneum of wild-type and
gal3–/– mice with sterile peritonitis, shown as mean (heavy horizontal lines) ± SD. Each data point represents the result from one mouse; seven mice of each genotype were used (
P < 0.01).
