Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
J. Clin. Invest. Marc K. Hellerstein, et al. 112:956 doi:10.1172/JCI17533 [
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Figure 1In vivo stable isotope labeling protocols. (
a) Long-term
2H
2O administration.
2H
2O was given daily for 9 weeks after a priming regimen. T cells and monocytes/granulocytes were sampled at times shown. Urine and saliva were sampled as shown, to measure body
2H
2O enrichment. (
b)
2H
2-glucose incorporation/die-away curves.
2H
2-glucose was given over 48 hours with follow-up blood draws for T cells as shown. Blood glucose enrichments were measured during the i.v.
2H
2-glucose infusion. Mono/granulo, monocytes/granulocytes; Glc, glucose. Arrows indicate times of stable isotope label administration or sample collection.