Jci_page_head_homepage_01 Jci_page_head_homepage_02
Barry M. Brenner
Published in Volume 110, Issue 12
J Clin Invest. 2002; 110(12):1753–1758 doi:10.1172/JCI17351
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Figure 1

Final common pathway for progression of chronic renal disease. Angiotensin II (ang II) promotes injury in at least five separate steps in the cycle. PGC, Glomerular capillary pressure; SNGFR, single-nephron GFR; GS, glomerulosclerosis; TIF, tubulo-interstitial fibrosis.