Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue
J. Clin. Invest. Susana Ortiz-Urda, et al. 111:251 doi:10.1172/JCI17193 [Go to this article.]

Figure 4
Restoration of anchoring fibrils after intradermal fibroblast injection. BMZ ultrastructure of human skin tissue regenerated on CB.17 scid/scid mice. Note the absence of anchoring fibrils in RDEB skin injected with RDEB^– fibroblasts (middle panel) and their restoration in RDEB skin injected with RDEB⁺ fibroblasts (right panel). Normal skin control (left panel) was produced using cells from normal subjects. Arrows denote representative anchoring fibrils. Scale bar: 500 nm. ld, lamina densa.