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Central role of RAGE-dependent neointimal expansion in arterial restenosis
Taichi Sakaguchi, Shi Fang Yan, Shi Du Yan, Dmitri Belov, Ling Ling Rong, Monica Sousa, Martin Andrassy, Steven P. Marso, Stephan Duda, Bernd Arnold, Birgit Liliensiek, Peter P. Nawroth, David M. Stern, Ann Marie Schmidt, Yoshifumi Naka
Published in Volume 111, Issue 7
J Clin Invest. 2003; 111(7):959–972 doi:10.1172/JCI17115
This article Copyright © 2003, The American Society for Clinical Investigation
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Figure 6

Effect of sRAGE on neointimal expansion in apoE null mice. (a–h) ApoE null mice were subjected to femoral artery guide-wire injury (day 1), and animals were treated with either sRAGE or MSA (100 μg/day, intraperitoneally, days 0–7) and sacrificed on day 28. Representative sections were treated with van Gieson’s elastic stain (a and b) or subjected to immunohistochemistry with anti-F4/80 IgG (d–g). The I/M ratio was determined on day 28 in the two groups of mice (c). (h) For 4/80-stained sections, image analysis was performed, and the area occupied by immunoreactive cells in the neointima and media was determined. These experiments employed at least eight vessels for each experimental condition, and the experiment was repeated twice. Scale bars: a, b, d, and f, 50 μm, and e and g, 25 μm.

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