JCI - Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A
J. Clin. Invest. 111:9 doi:10.1172/JCI17061 [Go to this article.]

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Figure 4

Histological analysis of floxed GC-A and CM GC-A KO hearts. Cardiomyocyte diameters and interstitial collagen fractions were estimated by quantitative morphometry of PAS-stained (a) or Sirius red–stained (b) ventricular sections, respectively. Black lines (a) indicate cardiomyocyte diameters in the region of the cell nucleus, which were significantly increased in CM GC-A KO hearts (c), without changes in interstitial collagen (d) (n = 16, *P < 0.05 vs. floxed GC-A).