Defective cardiac ion channels: from mutations to clinical syndromes
J. Clin. Invest. Colleen E. Clancy, et al. 110:1075 doi:10.1172/JCI16945 [Go to this article.]

Figure 2
The predicted transmembrane topology of domains I–IV of the cardiac Na⁺ channel α subunit encoded by SCN5A showing the location and nature of the mutations inducing LQTs, BrS, and isolated cardiac conduction disease.