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Does loss of bile acid homeostasis make mice melancholy?
David D. Moore
Published in Volume 110, Issue 8
J Clin Invest. 2002; 110(8):1067–1069 doi:10.1172/JCI16943
This article Copyright © 2002, The American Society for Clinical Investigation
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Figure 1

Formation of cholic acid (CA) from chenodeoxycholic acid (CDCA) by the microsomal cytochrome P450 enzyme sterol 12α-hydroxylase, which is encoded by the Cyp8b1 gene. The enzyme can also hydryoxylate other 7α-hydroxylated intermediates in the bile acid pathways (see ref. 13).

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