Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability
J. Clin. Invest. Huixing Wu, et al. 111:1589 doi:10.1172/JCI16889 [
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Figure 3Time course of inhibition of
E. coli K12 macromolecular synthesis by rat and human pulmonary collectins.
E. coli K12 were incubated in the presence of
3H-uridine (
a) or
14C-amino acids (
b and
c) and pulmonary collectins including hSP-A, rSP-A, or rSP-D for up to 2 hours. At the indicated time points, bacterial RNA or proteins were precipitated, collected on filters, and counted using a scintillation counter. Controls including no bacteria, no added protein, and heat-killed bacteria (heat) are shown. Data are mean ± SEM;
n = 3.
