Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability
J. Clin. Invest. Huixing Wu, et al. 111:1589 doi:10.1172/JCI16889 [
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Figure 1Modulation of
E. coli clearance from the lungs of pulmonary collectin mouse models. Bacterial CFUs in lung homogenates were quantified 6 hours after intratracheal inoculation with 5 × 10
6 E. coli in age- and inbred strain–matched SP-A
–/– and SP-A
+/+ C3H/HeN mice, or Swiss Black SP-D–overexpressing mice (+/+, rSP-D) and littermate controls (+/+). Data are mean ± SEM;
n = 10 per group; *
P < 0.05.
