GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
J. Clin. Invest. Rémy Burcelin, et al. 111:1555 doi:10.1172/JCI16888 [Go to this article.]

Figure 4
Glucose use rates of MGLUT4, MIRKO, and AMPK-DN mice and their respective controls infused with glucose into the portal vein. Glucose was infused through the portal vein in control (white bars) and mutant mice (black bars) for 180 min at a rate of ∼25 mg/kg/min. A ¹⁴C-2DG injection protocol was used to determine glucose use (ng/mg/min) by the diaphragm (Dia), the heart (Hea), the soleus muscle (Sol), the tibialis anterior (Tib) the vastus lateralis (VL), the white gonadal tissue (WAT), the brown interscapular adipose tissue (BAT), and the skin. (a) MGLUT4 mice; (b) MIRKO mice; (c) AMPK-DN mice. Eight to ten mice per group were studied. *Statistically different from controls; P < 0.05.