GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
J. Clin. Invest. Rémy Burcelin, et al. 111:1555 doi:10.1172/JCI16888 [Go to this article.]

Figure 3
Plasma insulin levels of MGLUT4, MIRKO, and AMPK-DN mice and their respective controls infused with glucose into the portal vein. Glucose was infused through the portal vein in control (white bars) and mutant mice (black bars) for 180 min at a rate of ∼25 mg/kg/min. Plasma insulin levels were determined from the tip of the tail vein before and 10, 30, 50, 120, and 180 min after the beginning of the glucose infusion and are reported as mean ± SE for eight to ten mice per group. The insets depict the corresponding AUC (μU/min/ml) for the different groups of mice. (a) MGLUT4 mice; (b) MIRKO mice; (c) AMPK-DN mice. *Statistically different from controls; P < 0.05.