GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
J. Clin. Invest. Rémy Burcelin, et al. 111:1555 doi:10.1172/JCI16888 [Go to this article.]

Figure 2
Blood glucose clearance of MGLUT4, MIRKO, and AMPK-DN mice and their respective controls infused with saline or glucose into the portal vein. Saline or glucose was infused through the portal vein in controls (white bars) and mutant mice (black bars) for 180 min at a rate of ∼25 mg/kg/min. A tritiated glucose coinfusion was performed to calculate whole body glucose turnover. Glucose clearance rates were then calculated as mean ± SE (ml/kg/min). Glucose-infused mice were studied in groups of eight to ten, and saline-infused mice were studied in groups of three to four. *Statistically different from controls; P < 0.05.