GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
J. Clin. Invest. Rémy Burcelin, et al. 111:1555 doi:10.1172/JCI16888 [Go to this article.]

Figure 1
Glycemic profiles of MGLUT4, MIRKO, and AMPK-DN mice and their respective controls infused with glucose into the portal vein. Glucose was infused through the portal vein in control (open squares) and mutant mice (filled squares) for 180 min at a rate of ∼25 mg/kg/min. The means ± SE of blood glucose was measured every 20 min. The insets depict the corresponding AUC (mM) for the different groups of mice. (a) MGLUT4 mice; (b) MIRKO mice; (c) AMPK-DN mice. Eight to ten mice were studied per group. *Statistically different from controls; P < 0.05.