Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
J. Clin. Invest. Ralf Küppers, et al. 111:529 doi:10.1172/JCI16624 [Go to this article.]

Figure 3
Identification of genes specifically expressed or downregulated in HL cell lines. Supervised cluster analysis using Genes@Work. Gene expression profiles of four HL cell lines were compared with four normal B cell subsets (five each of naive B cells, memory B cells, CBs and CCs), five LCL, seven DLCL cases, seven DLCL lines, four BL cases, eight BL lines, six FL, ten B-CLL. Matrices and gene ranking are as in Figure 2. The support value for supervised analysis was chosen as n = n₀, where n₀ is the number of cells in the given phenotype set, allowing for no unclustered sample per pattern in the phenotype set. Gene names are indicated. Twenty-seven distinct genes are significantly upregulated in the HL lines, and 45 distinct genes are downregulated (for one upregulated [IPL] and seven downregulated [Igα, Syk, Lck, CD20, PLCγ2, CD45, PTPN7] genes), each represented by two probes on the array; only the more significant probe is shown).