Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
J. Clin. Invest. Ralf Küppers, et al. 111:529 doi:10.1172/JCI16624 [
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Figure 3Identification of genes specifically expressed or downregulated in HL cell lines. Supervised cluster analysis using Genes@Work. Gene expression profiles of four HL cell lines were compared with four normal B cell subsets (five each of naive B cells, memory B cells, CBs and CCs), five LCL, seven DLCL cases, seven DLCL lines, four BL cases, eight BL lines, six FL, ten B-CLL. Matrices and gene ranking are as in Figure
2. The support value for supervised analysis was chosen as
n =
n0, where
n0 is the number of cells in the given phenotype set, allowing for no unclustered sample per pattern in the phenotype set. Gene names are indicated. Twenty-seven distinct genes are significantly upregulated in the HL lines, and 45 distinct genes are downregulated (for one upregulated [IPL] and seven downregulated [
Igα,
Syk,
Lck,
CD20,
PLCγ2,
CD45, PTPN7] genes), each represented by two probes on the array; only the more significant probe is shown).