FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice
J. Clin. Invest. Shinichi Yoshimura, et al. 112:1202 doi:10.1172/JCI16618 [Go to this article.]

Figure 3
Differentiation of BrdU-labeled cells into neurons within the GCL of DG after TBI. BrdU was injected on days 6, 7, and 8 after CCI or sham operation, and mice were killed on day 35. Coronal brain sections stained for BrdU immunoreactivity (cy2, green) and the neuronal marker, NeuN (cy3, red) were examined by laser scanning confocal microscopy (see Methods). The BrdU/NeuN-positive cells (yellow nuclei) were more numerous in FGF-2^+/+ (+/+) than in FGF-2^–/– (–/–) mice (see Table 1). Tissue section coordinate, bregma –2.5 mm. Scale bar: 20 μm.