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F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, I Kato, S Kobayashi, T Akiyama, S Takasawa, T Toyota, H Okamoto
J Clin Invest. 1998;
102(2):395
doi:10.1172/JCI1656
Abstract |
Full text
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C
yclic ADP-ribose (cADPR) has been shown to be a mediator for intracellular Ca2+ mobilization for insulin secretion by glucose in pancreatic beta cells, and CD38 shows both ADP-ribosyl cyclase to synthesize cADPR from NAD+ and cADPR hydrolase to hydrolyze cADPR to ADP-ribose. We show here that 13.8% of Japanese non-insulin-dependent diabetes (NIDDM) patients examined have autoantibodies against CD38 and that the sera containing anti-CD38 autoantibodies inhibit the ADP-ribosyl cyclase activity of CD38 (P </= 0.05). Insulin secretion from pancreatic islets by glucose is significantly inhibited by the addition of the NIDDM sera with anti-CD38 antibodies (P </= 0.04-0.0001), and the inhibition of insulin secretion is abolished by the addition of recombinant CD38 (P </= 0.02). The increase of cADPR levels in pancreatic islets by glucose was also inhibited by the addition of the sera (P </= 0.05). These results strongly suggest that the presence of anti-CD38 autoantibodies in NIDDM patients can be one of the major causes of impaired glucose-induced insulin secretion in NIDDM.
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(17)
| Title and authors |
Publication |
Year |
Design, Synthesis and Biological Evaluation of Noncovalent Inhibitors of Human CD38 NADase
Yi Zhou, Kai Yiu Ting, Connie Mo Ching Lam, Anna Ka Yee Kwong, Jie Xia, Hongwei Jin, Zhenming Liu, Liangren Zhang, Hon Cheung Lee, Lihe Zhang
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ChemMedChem
|
2012 |
Expression of CD38 with intracellular enzymatic activity: a possible explanation for the insulin release induced by intracellular cADPR
Yasuhiko Ohta, Akira Kitanaka, Keichiro Mihara, Osamu Imataki, Hiroaki Ohnishi, Terukazu Tanaka, Tomohiko Taminato, Yoshitsugu Kubota
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Mol Cell Biochem
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2011 |
CD38 through the life of a murine B lymphocyte
Felipe Vences-Catalán, Leopoldo Santos-Argumedo
|
IUBMB Life
|
2011 |
Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38
Hiroyo Ota, Shinji Tamaki, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Takashi Morioka, Shin Takasawa, Hiroshi Kimura
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Life Sciences
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2011 |
TRPM5 regulates glucose-stimulated insulin secretion
Lili R. Brixel, Mahealani K. Monteilh-Zoller, Claudia S. Ingenbrandt, Andrea Fleig, Reinhold Penner, Thorsten Enklaar, Bernhard U. Zabel, Dirk Prawitt
|
Pflugers Arch - Eur J Physiol
|
2010 |
Recent advances in physiological and pathological significance of NAD metabolites: roles of poly(ADP-ribose) and cyclic ADP-ribose in insulin secretion and diabetogenesis
Hiroshi Okamoto, Shin Takasawa
|
NRR
|
2009 |
CD38 at the junction between prognostic marker and therapeutic target
Silvia Deaglio, Semra Aydin, Tiziana Vaisitti, Luciana Bergui, Fabio Malavasi
|
Trends in Molecular Medicine
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2008 |
Anti-CD38 autoantibodies in type? diabetes
Roberto Mallone, Paolo Cavallo Perin
|
Diabetes Metab. Res. Rev.
|
2006 |
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.
Kazuya Togashi, Yuji Hara, Tomoko Tominaga, Tomohiro Higashi, Yasunobu Konishi, Yasuo Mori, Makoto Tominaga
|
EMBO J
|
2006 |
Anti-CD38 Autoimmunity in Children with Newly Diagnosed Type 1 Diabetes Mellitus
C. Pupilli,, A. Antonelli,, L. Iughetti,, G. D'Annunzio,, M. Cotellessa,, M. Vanelli,, H. Okamoto,, R. Lorini,, E. Ferrannini,
|
Journal of Pediatric Endocrinology and Metabolism
|
2005 |
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